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Centers of Excellence Sickle cell disease takes many forms, all of which occur when the gene for abnormal hemoglobin S combines with any other gene for abnormal hemoglobin. When one hemoglobin S gene combines with a second hemoglobin S gene, the result is probably the best known form of sickle cell disease – sickle cell anemia. Even though sickle cell anemia often refers to all types of sickle cell disease, it is only one type. The umbrella term “sickle cell disease” refers to the manifestations and complications of all severe forms of the disorder.
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